Cannabidiol (CBD) stormed the health and well-being industry.
In 2017, only the CBD retail sales of products derived from hemp, reached astounding $ 350 million, and by 2022 they are projected to become an industry with multibillion dollar. (1) Have you encountered oil CBD online or at a local store health food and wondered what the health benefits it can offer, and how to safely and effectively use it? Read on to learn how oil CBD works, how it can help you manage or improve certain conditions, as well as how to choose high-quality oil from a variety of options currently available on the market.
Have you considered trying CBD oil? Read this article to find out what health conditions may well affect the product, and get my recommendations on oils. #healthylifestyle # wellness #chriskresser
What is the CBD?
Cannabidiol is one of over 100 chemicals, known as cannabinoids, which are found in cannabis plants, including marijuana and marijuana. Cannabidiol (CBD) and its notorious nursing compound tetrahydrocannabinol (THC) are the two major cannabinoids cannabis.
Taking into account that the psychoactive THC and is responsible for the characteristic "high" people who have the use of marijuana, CBD is not,
CBD can be extracted from marijuana, which is cannabis with a high content of THC (usually 5 to 35 percent), or from cannabis, plants of the cannabis family with a very low content of THC less than 0.3 percent. (2) When the CBD is extracted from non-psychoactive cannabis, it is legal to buy in all 50 US states. However, CBD, made from marijuana, is legal only in states with medical or recreational marijuana legislation.
How does the CBD work?
Endocannabinoid system (ECS) is a network of signaling molecules derived from arachidonic acid that modulates many aspects of our biology, including central nervous system function, immunity and inflammation. Two primary endocannabinoids in our body are anandamide (AEA) and 2-arachidonoylglycerol. External sources of cannabinoids, such as cannabis, also interact with ECS. THC exerts its psychoactive effects, mainly by interacting with cannabinoid receptors in ECS. CBD, on the other hand, does not bind easily to cannabinoid receptors. Instead, it works by interacting with non-cannabinoid receptors by inhibiting the reuptake of the endocannabinoid own body. These different receptors affect functions ranging from serotonin neurotransmission to cell growth and survival.
CBD ECS also enhances activity by inhibiting the reuptake of endocannabinoids such as AEA and 2-arachidonoylglycerol. (3) This effect improves the overall ECS function of the body.
CBD also an allosteric receptor modulator, i.e. it may enhance or inhibit the transmission of signals between the cell receptors. For example, CBD enhances GABA receptor signaling by inhibiting excessive neurotransmission. This is probably one of the explanations for the soothing, anti-anxiety effect of CBD. (four)
It is obvious that the CBD is a complex compound with a variety of operating mechanisms, some of which can cause a variety of health benefits, as shown by new research.
Eight conditions that benefit from CBD oil
Although research in humans is ongoing, much remains to be done. CBD has already demonstrated a wide range of potential health benefits.s for people with diseases from autism to inflammatory bowel disease.
In many of these cases, CBD changes the course of the disease without the harmful side effects of pharmaceuticals. Here are eight cases where the results of the study are very encouraging.
Recent studies show that the ECS regulates neyropovedenie and immunity are two aspects of physiology, which significantly disrupted in autism. (5) This discovery has led to a growing interest in the use of cannabinoids to modulate the ECS autistic children, and we hope to reduce the symptoms of this disorder.
Several small studies show that CBD reduces the symptoms of autism, as well as related conditions, such as anxiety. A study conducted in Israel, 53 provided autistic child CBD oil at a dosage of 16 mg / kg per day; CBD oil also contained THC, but in very small quantities. After an average treatment duration of 66 days, children who received CBD showed a significant reduction in self-harm, rage, hyperactivity and sleep problems, all common symptoms of autism. (6) Another study which used the same oil CBD formula shown that CBD significantly improves anxiety, communication problems and destructive behavior. (7) Several more studies are currently underway to study the effects of the CBD on autism. (8, 9)
Several small human trials suggest that CBD is useful for reducing anxiety., In a group of healthy young men, a single dose of CBD 400 mg significantly reduced the anxiety that was reported, compared with placebo. (10) It was found that a single dose of 600 mg CBD reduces anxiety in patients with social phobia. (eleven) Interestingly, the anti-anxiety effects of CBD are usually observed at moderate doses of approximately 300 mg per day. Lower and higher doses either have no effect, or, paradoxically, increase anxiety. (12) Important note: Some people with anxiety may experience a paradoxical reaction with any dose of CBD.
CBD suppresses anxiety by interacting with several receptors of the central nervous system, which are known to regulate fear response, and anxiety-related behavior, including CB1R (cannabinoid receptor 1) and 5-HT1A. The activation of CB1R CBD promotes the “disappearance of fear”, a decrease in the conditioned reactions of fear, while the modulation of 5-HT1A CBD receptors reduces anxiety. (13)
3. Cancer (and side effects of treatment)
While medical marijuana has become popular to mitigate the side effects of cancer treatments, such as pain and nausea, the psychoactive effects of THC are undesirable for many cancer patients. Fortunately, research shows that CBD is a viable, non-psychoactive alternative that not only weakens the side effects of traditional cancer treatments, but also beneficially modulates the underlying cancer process.
In in vitro studies, it was found that the CBD regulates signaling pathways involved in cell proliferation and survival, inhibiting the development and progression of cancer. (14) It also stimulates autophagy, the process by which the body cleanses and restores the damaged cells with new ones. CBD can be useful in the treatment of glioma, melanoma, breast cancer and prostate cancer and, apparently, enhances the cytotoxic effects of chemotherapy. (15, 16, 17, 18, 19). While we are awaiting clinical trials exploring the potential of CBD as a cancer treatment, the excellent safety profile and beneficial effects of CBD oil for nausea and pain indicate that it can be a useful additional treatment to include in cancer treatment protocols today.
Every year in the United States, at least two million people suffer from antibiotic-resistant infections. Reducing the number of pharmaceutical preparations effective against bacteria resistant to antibiotics has led to increased interest in the use of natural compounds such as CDB, for the treatment of such infections. CBD has a strong antimicrobial activity against MRSA, widespread antibiotic resistant bacteria that infect humans. (20) This finding suggests that the CBD may be a valuable alternative pharmaceuticals for the treatment of MRSA and possibly other antibiotic-resistant infections.
5. Inflammatory bowel disease (IBD)
In studies, CBD demonstrated a positive effect on the symptoms and pathology of IBD, reducing tissue damage, production of reactive oxygen species, inducible activity of nitric oxide synthase and levels of TNF-alpha in the colon. (21, 22) CBD also supports the maintenance of the intestinal barrier, which is often impaired by IBD. (23)
Compared with preclinical studies, clinical trials of CBD on IBD are rare. A recent study showed that low doses of CBD (10 mg per day) were safe but not effective for Crohn's disease; however, the dose used in the trial was extremely low, and higher doses may be required to achieve a therapeutic effect. (24) Fortunately, additional clinical trials are awaiting the effects of CBD on IBD. (25)
6. Post Traumatic Stress Disorder (PTSD)
PTSD is known to be resistant to drug treatment and behavioral therapy. PTSD can occur after a traumatic experience, which leads to the memories, nightmares and extreme anxiety. Interestingly, new research suggests that CBD can improve the symptoms of PTSD by reducing the hyperactivity of the amygdala, the part of the brain involved in treating fear, thus suppressing traumatic memories. (26)
7. Pain and inflammation
CBD may be a viable option for treating various types of chronic pain. In animal studies, the actual CBD reduces pain and nerve damage in rat models of osteoarthritis. (27, 28) While research CBD for pain in humans is limited, CBD, seems to change the perception of pain, making it more bearable. (29, 30) currently being several high quality clinical trials to further investigate the effect of CBD on chronic neuropathic and post-operative pain. (31, 32)
Scientists have known for years that ECS is involved in convulsions; As a result, extensive studies have been carried out on the therapeutic use of cannabinoids for convulsions. (33) In 2018, the US FDA went down in history when it approved the preparation of the Epidiolex based on CBD for the treatment of two severe, rare childhood seizures – Lennox-Gastaut and Drave's syndromes.
Since CBD weakly binds to receptors CB1 and CB2, scientists believe that its anticonvulsant properties are likely due to the interaction with the non-cannabinoid receptors TRPV1, 5-HT1A and potential-controlled calcium channels. While many epileptic disorders do not respond to treatment with drugs, in many cases, CBD effectively suppresses them, without causing side effects or drug resistance associated with traditional contraceptive preparations.
CBD oil is also useful for many other conditions. It has anti-inflammatory and analgesic properties, which gives him the ability to offer therapeutic effects on a number of health problems, in addition to those listed here.
What to look for when buying a CBD
The CBD industry is a growing market with countless options available. You can choose an oil containing CBD, food, capsules, sprays and topical ointments and creams. However, as the federal government still considers illegal drug cannabis, CBD oil industry enough regulated by the FDA with very little supervision by a third party. This means that the quality and the recommended dosage of CBD products vary widely, which requires the ability of consumers to choose products CBD.
Read the label carefully.
A 2017 study published in JAMA tested cannabinoid levels in 84 CBD products from 31 companies. The researchers found that a shocking 69 percent of CBD products do not contain the amount of CBD, stated on the label, and 18 products contain THC. (34) In 2018, Consumer Lab published a product review on CBD extracts. In a survey of dozens of products CBD, they found that the dose of CBD to one proposed dose ranged from 1.3 to 22.3 mg, which is 15 times more! In addition, the cost of obtaining 10 mg of CBD from each product ranged from 0.80 to 4.73 dollars. (35)
When choosing a CBD oil product, carefully read the label and determine exactly how much CBD you receive and at what price. Look for foods that list the amount of CBD per serving; Products, which are indicated only "cannabinoids", do not provide information on how much CBD is contained in portions.
Consider Organic CBD Oil
In addition to the critical view of the CBD labeled products, you can also consider selecting CBD oils made from organically grown hemp. Pesticides applied to hemp and hemp during the growing process are delayed and can be concentrated during the production of CBD, as a result of which they end up in the final product. (36) Once you find the CBD product in which you are interested, contact the company to see if they are using methods of organic production.
My recommendations CBD Oil
Today, hundreds, if not thousands of CBD products are on the market. Unfortunately, according to a recent survey ConsumerLab.com, many of these products do not contain CBD dose indicated on the label.
According to ConsumerLab.com, the best option – both in terms of efficiency and price per milligram – is the concentrated formula Bluebird Botanicals Hemp Classic 6x and their Plus CBD Oil Hemp soft capsules. Their products also use organic hemp seed oil, and they do not contain GMOs.
Elixinol Natural Drops hemp extract coconut oil + – another version of a high concentration of CBD and competitive price per milligram. However, it does not contain some of the other cannabinoids found in cannabis, because it is made from the extract of hemp; It is made from hemp oil, with added CBD.
Sol CBD is another company that offers products with a CBD concentration. They have a liposomal version that can be better absorbed, and they have cinnamon flavored tincture, which many of my patients consider to be more delicious than standard CBD preparations. The disadvantage is that Sol CBD products are about twice as expensive as Bluebird Botanicals.
If you are looking for the actual CBD product that can be applied directly to the painful area, Nature's Love offers organic cream with extract of the full range of hemp. Mary & # 39; s Nutritionals Muscle Freeze is another topical option for muscle pain.
For all CBD products, I recommend starting with the recommended dose on the bottle. and gradually increasing the dose until you notice an improvement.
You can also increase the bioavailability of CBD by eating it with food that contains fat. Healthy fats enhance the absorption of CBD by the intestinal lymphatic system. (37)
Who should avoid the CBD?
CBD should not be used during pregnancy and lactation because the CBD effect on the growing fetus and child are poorly understood. However, it is known that THC crosses the placenta and passes into breast milk, and it is likely that the CBD does the same thing.
You may also need to avoid CBD or consult a doctor before trying to take it if you are taking any pharmaceutical preparations that are metabolized by cytochrome P450 (CYP450) enzymes. CBD interacts with the CYP450 enzymes and may enhance or inhibit the metabolism of drugs which pass through the system. Does the suppression or enhancement depends on the CBD dosage, dosage medications and unique human genetics and biochemistry.
Sixty percent of prescription drugs are metabolized by the CYP450 system; If you are taking any of the medicines in this list, please consult your doctor before trying the CBD: (38)
- Angiotensin II Blockers
- Beta blockers
- Calcium channel blockers
- Antivirals against HIV
- HMG CoA reductase inhibitors (statins)
- Immune Modulators
- Oral hypoglycemic agents
Now I want to hear from you. Have you considered trying CBD oil? If you have already tried this, what was your experience? Let me know in the comments below.